Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

The increasing worldwide prevalence of obesity is partially related to the ready availability of
highly palatable foods which increases the incidence of hedonic, non-homeostatic feeding …

Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

Rhythmic gene expression is found throughout the central nervous system. This harmonized
regulation can be dependent on-and independent of-the master regulator of biological …

Maintaining healthy body weight is increasingly difficult in our obesogenic environment.
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

Brief, high-concentration (phasic) spikes in nucleus accumbens dopamine critically
participate in aspects of food reward. Although physiological state (eg, hunger, satiety) and …

Overconsumption of dietary fat is increasingly linked with motivational and emotional
impairments. Human and animal studies demonstrate associations between obesity and …

Neurotransmitters (NTs) are biologically active chemicals, which mediate the
electrochemical transmission between neurons. NTs control numerous organic functions …

The aim of this review is to explore how metabolic changes induced by diets high in
saturated fat (HFD) affect nucleus accumbens (NAc) dopamine neurotransmission and food …