While there is considerable contemporary interest in elucidating the role of placenta-derived
extracellular vesicles in normal and complicated pregnancies and their utility as biomarkers …

One of the primary regulators of maternofetal glucose transfer is the density of glucose
transporter proteins in the placenta. These transporters, members of the GLUT gene family …

The excitement and controversy surrounding the potential role of human embryonic stem
(ES), cells in transplantation therapy have often overshadowed their potentially more …

Background Human placenta releases specific nanovesicles (ie exosomes) into the
maternal circulation during pregnancy, however, the presence of placenta-derived …

OBJECTIVES: Cell lines derived from human ovarian and endometrial cancers, and their
immortalized non-malignant counterparts, are critical tools to investigate and characterize …

Introduction Placenta-derived exosomes may represent an additional pathway by which the
placenta communicates with the maternal system to induce maternal vascular adaptations to …

Impaired trophoblast invasiveness and spiral arterial remodelling, which results in poor
placental perfusion during early pregnancy, is believed to cause fetal injury and growth …

Background In the absence of clinical folate deficiency, periconceptional supplementation
with folic acid reduces a woman's risk of having an infant with a neural-tube defect. Since …

Objective. Placentas are oxidatively stressed during preeclampsia and produce more tumor
necrosis factor α (TNFα) and more thromboxane than normal. Oxidative stress may cause …

Objective Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and
preterm prelabor rupture of the membranes (pPROM); however, the precise mechanistic role …