Recent rapid biotechnological breakthroughs have led to the identification of complex and
unique molecular features that drive malignancies. Precision medicine has exploited next …

Real-world data (RWD) are rapidly emerging sources of information for patients, clinicians
and regulators. While randomized controlled trials (RCTs) reduce bias and confounding …

Replacing RCTs with real world data for regulatory decision making: a self-fulfilling prophecy? |
The BMJ Skip to main content Intended for healthcare professionals Access provided by Google …

Importance Cancer registries are important real-world data sources consisting of data
abstraction from the medical record; however, patients with unknown or missing data are …

Randomized controlled trials (RCTs) evaluating anti-cancer agents often lack
generalizability to real-world oncology patients. Although restrictive eligibility criteria …

Importance Although longer times from breast cancer diagnosis to primary surgery have
been associated with worse survival outcomes, the specific time point after which it is …

Background The aim of this study was to assess the effect of a multimodal prehabilitation
program on perioperative outcomes in colorectal cancer patients with a higher postoperative …

Objective To explore how design emulation and population differences relate to variation in
results between randomised controlled trials (RCT) and non-randomised real world …

Importance In March 2023, the National Comprehensive Cancer Network endorsed watch
and wait for those with complete clinical response to total neoadjuvant therapy. Neoadjuvant …

PURPOSE Given the heterogeneity and improvement in outcomes for metastatic breast
cancer (MBC), we developed a staging system that refines prognostic estimates for patients …