Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Aging of cerebral white matter

H Liu, Y Yang, Y **a, W Zhu, RK Leak, Z Wei… - Ageing research …, 2017 - Elsevier
White matter (WM) occupies a large volume of the human cerebrum and is mainly composed
of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are …

Identifying the distinct cognitive phenotypes in multiple sclerosis

E De Meo, E Portaccio, A Giorgio, L Ruano… - JAMA …, 2021 - jamanetwork.com
Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Cognitive impairment in multiple sclerosis–a review of current knowledge and recent research

T Grzegorski, J Losy - Reviews in the Neurosciences, 2017 - degruyter.com
Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that is
characterised by inflammatory damage to the myelin sheath. Though often neglected …

The hippocampus in multiple sclerosis

MA Rocca, F Barkhof, J De Luca, J Frisén… - The Lancet …, 2018 - thelancet.com
Some of the clinical manifestations of multiple sclerosis, such as memory impairment and
depression, are, at least partly, related to involvement of the hippocampus. Pathological …

The prevalence of cognitive impairment in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis

W Wu, H Francis, A Lucien, TA Wheeler… - Neuropsychology …, 2024 - Springer
It is increasingly recognized that cognitive symptoms are a common sequelae of relapsing-
remitting multiple sclerosis and are associated with adverse functional consequences …

Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

M Di Filippo, A Mancini, L Bellingacci, L Gaetani… - Cell reports, 2021 - cell.com
Cognitive impairment (CI) is a disabling concomitant of multiple sclerosis (MS) with a
complex and controversial pathogenesis. The cytokine interleukin-17A (IL-17A) is involved …

Neuropsychology of multiple sclerosis: looking back and moving forward

RHB Benedict, J DeLuca, C Enzinger… - Journal of the …, 2017 - cambridge.org
The neuropsychological aspects of multiple sclerosis (MS) have evolved over the past three
decades. What was once thought to be a rare occurrence, cognitive dysfunction is now …

Role of oligodendrocyte dysfunction in demyelination, remyelination and neurodegeneration in multiple sclerosis

AO Dulamea - Multiple Sclerosis: Bench to Bedside: Global …, 2017 - Springer
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …