Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF),
remains challenging as current available antifibrotic agents are not effective in halting …

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix
proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified …

Background and aim Systemic sclerosis (SSc) is an immune mediated connective tissue
disease characterized by microvascular dysfunction, aberrant immune response, and …

Renal fibrosis is now recognized as a main determinant of renal pathology to include
chronic kidney disease. Deposition of pathological matrix in the walls of glomerular …

Disruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within
tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are …

Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac
phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM …

Following acute myocardial ischemia reperfusion (MIR), macrophages infiltrate damaged
cardiac tissue and alter their polarization phenotype to respond to acute inflammation and …

Renal fibrosis is an important pathological biomarker of chronic kidney disease (CKD).
Stimulator of interferon genes/TANK binding kinase 1 (STING/TBK1) axis has been identified …