This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

A growing collection of bacterial riboswitch classes is being discovered that sense central
metabolites, coenzymes, and signaling molecules. Included among the various mechanisms …

More than 55 distinct classes of riboswitches that respond to small metabolites or elemental
ions have been experimentally validated to date. The ligands sensed by these riboswitches …

Specimens below 50 kDa have generally been considered too small to be analyzed by
single-particle cryo-electron microscopy (cryo-EM). The high flexibility of pure RNAs makes it …

The aptamer portions of previously reported riboswitch classes that sense guanine, adenine,
or 2′-deoxyguanosine are formed by a highly similar three-stem junction with distinct …

Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer
domain result in ordinary dose-response curves that require approximately a 100-fold …

Growing RNAs fold differently as they are transcribed, which modulates their finally adopted
structures. Riboswitches regulate gene expression by structural change, which are sensitive …

The nadA motif is a riboswitch candidate present in various Acidobacteria species that was
previously identified by bioinformatic analysis of bacterial DNA data sets. More than 100 …

A bacterial noncoding RNA motif almost exclusively associated with pnuC genes was
uncovered using comparative sequence analysis. Some PnuC proteins are known to …

Riboswitches are highly conserved RNA elements that located in the 5′-UTR of mRNAs,
which undergo real-time structure conformational change to achieve the regulation of …