TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …
migration, and the differentiation of a plethora of different cell types. Consistent with these …
[HTML][HTML] Emerging roles of lncRNA in cancer and therapeutic opportunities
MC Jiang, JJ Ni, WY Cui, BY Wang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Cancer is difficult to cure due to frequent metastasis, and develo** effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …
Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …
Inflammation and pancreatic cancer: focus on metabolism, cytokines, and immunity
Systemic and local chronic inflammation might enhance the risk of pancreatic ductal
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …
Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance-A review
Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The
lack of reliable means of early cancer detection contributes to this disease's dismal …
lack of reliable means of early cancer detection contributes to this disease's dismal …
YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect
Y Hou, Q Zhang, W Pang, L Hou, Y Liang… - Cell Death & …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It
thrives in a malnourished environment; however, little is known about the mechanisms by …
thrives in a malnourished environment; however, little is known about the mechanisms by …
Circulating tumor cells: from new biological insights to clinical practice
X Gu, S Wei, X Lv - Signal Transduction and Targeted Therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …
tumor cells migrate through the bloodstream from the original site to other parts of the body …
Investigating the regulatory role of miRNAs as silent conductors in the management of pathogenesis and therapeutic resistance of pancreatic cancer
Pancreatic cancer (PC) has the greatest mortality rate of all the main malignancies. Its
advanced stage and poor prognosis place it at the bottom of all cancer sites. Hence …
advanced stage and poor prognosis place it at the bottom of all cancer sites. Hence …
RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer
Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and
is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are …
is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are …