Green synthesis of hydrazono-thiazolones using vitamin B1 and their antibacterial implications

SM Gomha, SM Riyadh, B Farag… - … Chemistry Letters and …, 2024 - Taylor & Francis
The study focuses on green methodologies in synthetic organic chemistry, emphasizing the
use of thiamine hydrochloride (Vitamin B1) as an eco-friendly catalyst for synthesizing …

Evaluation of the in vitro anti-inflammatory and anti-Helicobacter pylori activities of chitosan-based biomaterials modified with copper oxide nanoparticles

NY Elmehbad, NA Mohamed, NA Abd El-Ghany… - International Journal of …, 2023 - Elsevier
For chemical modification, p-aminobenzoic acid was incorporated into chitosan Schiff base
(ACsSB) and chitosan (ACs). Two ACs-based CuO nanoparticles composites; ACs/CuONPs …

Recent studies on protein kinase signaling inhibitors based on thiazoles: review to date

MS Ebaid, HAA Ibrahim, AF Kassem, A Sabt - RSC advances, 2024 - pubs.rsc.org
Due to the important role of protein kinases in protein phosphorylation within vital cellular
processes, their abnormal function, especially in cancer situations, has underscored their …

[HTML][HTML] Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1, 3-dione moiety as …

WA Mokbel, MA Hosny, SM Gomha, MEA Zaki… - Results in …, 2024 - Elsevier
To highlight the importance of thiazole and thiadiazole derivatives in the progression of
cancer and microbial treatments and to aid in drug design, we have synthesized a new …

Chitosan–sulfonic acid-catalyzed green synthesis of naphthalene-based azines as potential anticancer agents

AYA Alzahrani, SM Gomha, MEA Zaki… - Future Medicinal …, 2024 - Taylor & Francis
Aim: This study focuses on advancing green chemistry in anticancer drug discovery,
particularly through the synthesis of azine derivatives with a naphthalene core using CS …

Insights into bacterial interactions: Comparing fluorine-containing 1, 2, 4-triazoles to antibiotics using molecular docking and molecular dynamics approaches

N Korol, O Holovko-Kamoshenkova, R Mariychuk… - Heliyon, 2024 - cell.com
Understanding the interactions between drugs and enzymes is crucial for designing effective
therapeutics. This study employed a combination of molecular docking and molecular …

Grinding-assisted synthesis of novel arylhydrazono curcumin analogues and bis-pyrazolines as cyclin-dependent kinases (CDKs) inhibitors

SM Gomha, SM Riyadh, AAAA El-Sayed… - Inorganic Chemistry …, 2024 - Elsevier
The grinding method, an environmentally friendly technique in green chemistry, was
employed for the efficient synthesis of heterocyclic compounds, specifically symmetrical …

Facile one-pot synthesis and in silico study of new heterocyclic scaffolds with 4-pyridyl moiety: Mechanistic insights and X-ray crystallographic elucidation

FM Abdelrazek, MEA Zaki, SA Al-Hussain, B Farag… - Heliyon, 2024 - cell.com
Acetylpyridine 1 and malononitrile 2 were allowed to react in a 3MCRs with dimedone 3a or
cyclohexa-1, 3-dione 3b under reflux to afford 4-methyl-4-(pyridin-4-yl)-5, 6, 7, 8-tetrahydro …

[HTML][HTML] Design, synthesis, in vitro biological assessment and in silico molecular modeling study of thiazole-thiazolidinone derivatives as potent anti-cancer agents

S Khan, H Ullah, R Hussain, MU Khan, Y Khan… - Results in …, 2024 - Elsevier
The current study addressed the synthesis of thiazole-based thiazolidinone derivatives (1–
18) using stepwise reaction processes, and their structure was confirmed using various …