Natural products for drug discovery in the 21st century: innovations for novel drug discovery

NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

The role of natural products as sources of therapeutic agents for innovative drug discovery

K Dzobo - Comprehensive pharmacology, 2022 - pmc.ncbi.nlm.nih.gov
Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

[HTML][HTML] Medicinal plants used in the treatment of human immunodeficiency virus

B Salehi, NVA Kumar, B Şener, M Sharifi-Rad… - International journal of …, 2018 - mdpi.com
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected
around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There …

Therapeutic potentials of antiviral plants used in traditional African medicine with COVID-19 in focus: A Nigerian perspective

AF Attah, AA Fagbemi, O Olubiyi… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic is caused by an infectious novel strain
of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Critical evaluation of causality assessment of herb–drug interactions in patients

C Awortwe, M Makiwane, H Reuter… - British journal of …, 2018 - Wiley Online Library
The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to
herb–drug interactions (HDI) in patients taking herbs and prescribed medications based on …

Structure-activity-relationship and mechanistic insights for anti-HIV natural products

R Kaur, P Sharma, GK Gupta, F Ntie-Kang, D Kumar - Molecules, 2020 - mdpi.com
Acquired Immunodeficiency Syndrome (AIDS), which chiefly originatesfroma retrovirus
named Human Immunodeficiency Virus (HIV), has impacted about 70 million people …

PharmVar GeneFocus: CYP2B6

Z Desta, A El‐Boraie, L Gong… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature
for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus …

[HTML][HTML] Plants-derived biomolecules as potent antiviral phytomedicines: new insights on ethnobotanical evidences against coronaviruses

AJ Siddiqui, C Danciu, SA Ashraf, A Moin, R Singh… - Plants, 2020 - mdpi.com
SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is
destroying the world economy and social life, with increased mortality rate each day. To …

Five priorities of African genomics research: the next frontier

A Wonkam, NS Munung, C Dandara… - Annual Review of …, 2022 - annualreviews.org
To embrace the prospects of accurately diagnosing thousands of monogenic conditions,
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …

Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies

M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …