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The expanding regulatory mechanisms and cellular functions of circular RNAs
LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
The biogenesis and emerging roles of circular RNAs
LL Chen - Nature reviews Molecular cell biology, 2016 - nature.com
Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of
thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels …
thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels …
Global detection of human variants and isoforms by deep proteome sequencing
An average shotgun proteomics experiment detects approximately 10,000 human proteins
from a single sample. However, individual proteins are typically identified by peptide …
from a single sample. However, individual proteins are typically identified by peptide …
Ageing-associated changes in transcriptional elongation influence longevity
C Debès, A Papadakis, S Grönke, Ö Karalay, LS Tain… - Nature, 2023 - nature.com
Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …
Comparative transcriptomics reveals human-specific cortical features
The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …
cellular substrates are poorly understood. We used comparative single-nucleus …
Alternative splicing during mammalian organ development
Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species
comparisons have been largely restricted to adult tissues and the functionality of most AS …
comparisons have been largely restricted to adult tissues and the functionality of most AS …