Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other growth
factors are widely used in orthopaedic/sports medicine to repair injured tendons. While PRP …

Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is
expressed on sensory nerves to cause neurogenic inflammation. Transient receptor …

Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …

Proteinase-activated receptor (PAR)-2, a G-protein-coupled receptor for trypsin and mast
cell tryptase, is highly expressed in the intestine. Luminal trypsin and tryptase are elevated …

The advent of cancer immunotherapy based on PD-1 and CTLA-4 immune checkpoint
blockade (ICB) has revolutionized cancer treatment. However, many cancers do not respond …

Background & Aims: Ghrelin is a novel growth hormone-releasing peptide with potential
endogenous anti-inflammatory activities ameliorating some pathologic inflammatory …

Proteinase-activated receptor (PAR) 2 is expressed on a subset of primary afferent neurons
and involved in inflammatory nociception. Transient receptor potential vanilloid subfamily 1 …

Inflammatory bowel disease (IBD), the most important being Crohn's disease and ulcerative
colitis, results from chronic dysregulation of the mucosal immune system in the …