Harnessing nanomaterials for cancer sonodynamic immunotherapy

S Liang, J Yao, D Liu, L Rao, X Chen… - Advanced …, 2023‏ - Wiley Online Library
Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …

Piezoelectric nanomaterials activated by ultrasound: the pathway from discovery to future clinical adoption

A Cafarelli, A Marino, L Vannozzi, J Puigmartí-Luis… - ACS …, 2021‏ - ACS Publications
Electrical stimulation has shown great promise in biomedical applications, such as
regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical …

Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound

Z Xu, TL Hall, E Vlaisavljevich… - International Journal of …, 2021‏ - Taylor & Francis
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology
guided by real-time imaging. Using focused ultrasound delivered from outside the body …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024‏ - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies

RJE van den Bijgaart, DC Eikelenboom… - Cancer Immunology …, 2017‏ - Springer
Tumor ablation technologies, such as radiofrequency-, cryo-or high-intensity focused
ultrasound (HIFU) ablation will destroy tumor tissue in a minimally invasive manner. Ablation …

[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy

KB Bader, E Vlaisavljevich, AD Maxwell - Ultrasound in medicine & biology, 2019‏ - Elsevier
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

[HTML][HTML] Applications of focused ultrasound for the treatment of glioblastoma: a new frontier

AM Hersh, M Bhimreddy, C Weber-Levine, K Jiang… - Cancers, 2022‏ - mdpi.com
Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …

Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy

S Qu, T Worlikar, AE Felsted, A Ganguly… - Journal for …, 2020‏ - pmc.ncbi.nlm.nih.gov
Background Develo** the ability to use tumor-directed therapies to trigger potentially
therapeutic immune responses against cancer antigens remains a high priority for cancer …

Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation

AL Pepple, JL Guy, R McGinnis, AE Felsted… - Frontiers in …, 2023‏ - frontiersin.org
Introduction Histotripsy is a novel focused ultrasound tumor ablation modality with potent
immunostimulatory effects. Methods To measure the spatiotemporal kinetics of local …

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

K Hynynen, RM Jones - Physics in Medicine & Biology, 2016‏ - iopscience.iop.org
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …