Mitochondria are specialized compartments that produce requisite ATP to fuel cellular
functions and serve as centers of metabolite processing, cellular signaling, and apoptosis …

Although the large majority of mitochondrial proteins are nuclear encoded, for their correct
functioning mitochondria require the expression of 13 proteins, two rRNA, and 22 tRNA …

Mitochondrial DNA (mtDNA) harbors essential genes in most metazoans, yet the regulatory
impact of the multiple evolutionary mtDNA rearrangements has been overlooked. Here, by …

Alzheimer's Disease (AD) is the main cause of dementia and it is defined by cognitive
decline coupled to extracellular deposit of amyloid-beta protein and intracellular …

Natural selection acts on the phenotype. Therefore, many mistakenly expect to observe its
signatures only in the organism, while overlooking its impact on tissues, cells and …

Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA
(mtDNA). Hundreds to thousands of copies of mtDNA exist in each cell, yet because …

Mitochondrial DNA (mtDNA) is indispensable for mitochondrial function and is maintained
by DNA repair, turnover, mitochondrial dynamics and mitophagy, along with the inherent …

Mitochondria have a plethora of functions in eukaryotic cells, including cell signaling,
programmed cell death, protein cofactor synthesis, and various aspects of metabolism. The …

Heat shock factor–1 (HSF-1) is a master regulator of stress responses across taxa.
Overexpression of HSF-1 or genetic ablation of its conserved negative regulator, heat shock …

Our understanding of the molecular regulation of aging and age-related diseases is still in its
infancy, requiring in-depth characterization of the molecular landscape sha** these …