Cell cycle control in cancer
Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
Coordinating gene expression during the cell cycle
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
The broken cycle: E2F dysfunction in cancer
LN Kent, G Leone - Nature Reviews Cancer, 2019 - nature.com
The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …
driving cell cycle progression, dictating the timing and fidelity of genome replication and …
Mitochondria as playmakers of apoptosis, autophagy and senescence
Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …
species. They are responsible for managing cell life and death by a balanced homeostasis …
Integration of multiomics data with graph convolutional networks to identify new cancer genes and their associated molecular mechanisms
The increase in available high-throughput molecular data creates computational challenges
for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …
for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …
The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation
Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …
Control of cell cycle transcription during G1 and S phases
The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …
Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy
J Yao, M Yang, Y Duan - Chemical reviews, 2014 - ACS Publications
2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the
development of resistance to chemotherapy affecting over 30% of patients. New …
development of resistance to chemotherapy affecting over 30% of patients. New …