Herpesviruses infect virtually all humans and establish lifelong latency and reactivate to
infect other humans. Latency requires multiple functions: maintaining the herpesvirus …

Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …

Background and main text Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is
a complex and controversial clinical condition without having established causative factors …

Virus infections usually begin in peripheral tissues and can invade the mammalian nervous
system (NS), spreading into the peripheral (PNS) and more rarely the central (CNS) nervous …

SUMMARY Human herpesvirus 6 (HHV-6) is a widespread betaherpesvirus which is
genetically related to human cytomegalovirus (HCMV) and now encompasses two different …

Recent studies have uncovered myriad viral sequences that are integrated
or'endogenized'in the genomes of various eukaryotes. Surprisingly, it appears that not just …

Skin disease due to viruses may be a primary infection of the epidermis or may arise
secondary to systemic infection. Depending on the virus, the effects may be necrotic damage …

Integration into the nuclear genome of germ line cells can lead to vertical inheritance of
retroviral genes as host alleles. For other viruses, germ line integration has only rarely been …

The large diversity of viruses that exist in human populations are potentially excreted into
sewage collection systems and concentrated in sewage sludge. In the US, the primary fate …