Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable
body weight, because overall caloric ingestion and expenditure are exquisitely matched …

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OBJECTIVE—To examine the mechanisms of action, therapeutic potential, and challenges
inherent in the use of incretin peptides and dipeptidyl peptidase-IV (DPP-IV) inhibitors for the …

Context Energy balance is critical for survival and health, and control of food intake is an
integral part of this process. This report reviews hormonal signals that influence food intake …

BACKGROUND: Peripheral administration of glucagon-like peptide-1 (GLP-1) for four hours,
to normal weight and obese humans, decreases food intake and suppresses appetite …

Despite dramatic fluctuations in calorie intake, animals maintain a very stable body weight.
The reason is that energy intake and expenditure are precisely matched. Long-term …

The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an …

Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …

The glucagon-like peptides GLP-1 and GLP-2 are produced in enteroendocrine L cells of
the small and large intestine and secreted in a nutrient-dependent manner. GLP-1 regulates …