Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Y Yang, S Li, Y Wang, Y Zhao, Q Li - Signal transduction and targeted …, 2022 - nature.com
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors
The discovery that mutations in the EGFR gene are detected in up to 50% of lung
adenocarcinoma patients, along with the development of highly efficacious epidermal …
adenocarcinoma patients, along with the development of highly efficacious epidermal …
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …
Coregulation of pathways in lung cancer patients with EGFR mutation: therapeutic opportunities
Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma are a frequent
class of driver mutations. Single EGFR tyrosine kinase inhibitor (TKI) provides substantial …
class of driver mutations. Single EGFR tyrosine kinase inhibitor (TKI) provides substantial …
Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex
YY Chu, MK Chen, Y Wei, HH Lee, W **a, YN Wang… - Nature Cancer, 2022 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising
clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a …
clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a …
Suppression of EGFR/PKC-δ/NF-κB signaling associated with imipramine-inhibited progression of non-small cell lung cancer
Background Anti-depressants have been reported to own anti-tumor potential types of
cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not …
cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not …
TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance
Osimertinib (AZD9291) has been widely used for the treatment of EGFR mutant non-small
cell lung cancer. However, resistance to osimertinib is inevitable. In this study we elucidated …
cell lung cancer. However, resistance to osimertinib is inevitable. In this study we elucidated …
[HTML][HTML] Phosphorylation regulates cullin-based ubiquitination in tumorigenesis
Y Chen, X Shao, J Cao, H Zhu, B Yang, Q He… - … Pharmaceutica Sinica B, 2021 - Elsevier
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and
degradation, and can be targeted for disease treatment when the abnormal expression of …
degradation, and can be targeted for disease treatment when the abnormal expression of …
PKCα and PKCδ: friends and rivals
JD Black, T Affandi, AR Black, ME Reyland - Journal of Biological Chemistry, 2022 - ASBMB
PKC comprises a large family of serine/threonine kinases that share a requirement for
allosteric activation by lipids. While PKC isoforms have significant homology, functional …
allosteric activation by lipids. While PKC isoforms have significant homology, functional …
An Update on Protein Kinases as Therapeutic Targets—Part I: Protein Kinase C Activation and Its Role in Cancer and Cardiovascular Diseases
Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …