Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …

Nucleic acid‐based therapeutics that regulate gene expression have been developed
towards clinical use at a steady pace for several decades, but in recent years the field has …

Engineered tissues can be used to model human pathophysiology and test the efficacy and
safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered …

New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …

An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …

Microphysiological systems (MPS) consisting of multiple linked organ-on-a-chip (OoC)
components are highly promising tools with potential to provide more relevant in vitro to in …

One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …

The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

Organ-on-a-chip (OoC) is a new and promising technology, which aims to improve the
efficiency of drug development and realize personalized medicine by simulating in vivo …

Diabetes mellitus (DM) is a very serious disease, the incidence of which has been
increasing worldwide. The beginning of diabetic research can be traced back to the 17th …