Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
c-Src and EGFR inhibition in molecular cancer therapy: what else can we improve?
S Belli, D Esposito, A Servetto, A Pesapane… - Cancers, 2020 - mdpi.com
The proto-oncogene c-Src is a non-receptor tyrosine kinase playing a key role in many
cellular pathways, including cell survival, migration and proliferation. c-Src de-regulation has …
cellular pathways, including cell survival, migration and proliferation. c-Src de-regulation has …
Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells
We describe a microchip designed to quantify the levels of a dozen cytoplasmic and
membrane proteins from single cells. We use the platform to assess protein–protein …
membrane proteins from single cells. We use the platform to assess protein–protein …
CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteosarcoma microenvironment
Chemokines modulate angiogenesis and metastasis that dictate cancer development in
tumor microenvironment. Osteosarcoma is the most frequent bone tumor and is …
tumor microenvironment. Osteosarcoma is the most frequent bone tumor and is …
Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells
CW Lin, WC Hou, SC Shen, SH Juan, CH Ko… - …, 2008 - academic.oup.com
Abstract Quercetin (QUE; 3, 5, 7, 3′, 4′-tetrahydroxyflavone) has been shown to possess
several beneficial biological activities including antitumor, anti-inflammation and antioxidant …
several beneficial biological activities including antitumor, anti-inflammation and antioxidant …
Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations
Q He, M Qu, H Bao, Y Xu, T Shen, D Tan… - Cytokine & Growth …, 2023 - Elsevier
Epidermal growth factor receptor (EGFR) mutation is the most common driver mutation in
non-small cell lung cancer (NSCLC). The first-line therapy for advanced NSCLC patients …
non-small cell lung cancer (NSCLC). The first-line therapy for advanced NSCLC patients …
Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
The aim of the present study was to examine the cytoprotective effect of eckol, a
phlorotannin found in Ecklonia cava and to elucidate underlying mechanisms. Heme …
phlorotannin found in Ecklonia cava and to elucidate underlying mechanisms. Heme …
EGFR family and Src family kinase interactions: mechanics matters?
Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion
molecules, such as integrins, have historically been viewed to have distinctly separable …
molecules, such as integrins, have historically been viewed to have distinctly separable …
Protein kinase C (PKC) isozymes and cancer
JH Kang - New Journal of Science, 2014 - Wiley Online Library
Protein kinase C (PKC) is a family of phospholipid‐dependent serine/threonine kinases,
which can be further classified into three PKC isozymes subfamilies: conventional or classic …
which can be further classified into three PKC isozymes subfamilies: conventional or classic …
Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies
MS Ahluwalia, J de Groot, WM Liu, CL Gladson - Cancer letters, 2010 - Elsevier
Glioblastoma (GBM) is an extremely aggressive, infiltrative tumor with a poor prognosis. The
regulatory approval of bevacizumab for recurrent GBM has confirmed that molecularly …
regulatory approval of bevacizumab for recurrent GBM has confirmed that molecularly …