Comet assay: a versatile but complex tool in genotoxicity testing
E Cordelli, M Bignami, F Pacchierotti - Toxicology Research, 2021 - academic.oup.com
The comet assay is a versatile method for measuring DNA strand breaks in individual cells. It
can also be applied to cells isolated from treated animals. In this review, we highlight …
can also be applied to cells isolated from treated animals. In this review, we highlight …
Mode of action-based risk assessment of genotoxic carcinogens
A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …
Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA
Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …
products. Recent evidence suggests that many of these chemicals are measureable in …
[HTML][HTML] An update on formaldehyde adulteration in food: sources, detection, mechanisms, and risk assessment
Formaldehyde is added illegally to food to extend its shelf life due to its antiseptic and
preservation properties. Several research has been conducted to examine the …
preservation properties. Several research has been conducted to examine the …
A review of the presence of formaldehyde in fish and seafood
Fish is an excellent source for high-quality protein, good fat (omega 3 and 6), vitamins (B, D),
and minerals (Ca, P, Zn, I, Mg, K, etc.) and can lower blood pressure and help reduce the …
and minerals (Ca, P, Zn, I, Mg, K, etc.) and can lower blood pressure and help reduce the …
Trends in the application of high-resolution mass spectrometry for human biomonitoring: an analytical primer to studying the environmental chemical space of the …
Global profiling of xenobiotics in human matrices in an untargeted mode is gaining attention
for studying the environmental chemical space of the human exposome. Defined as the …
for studying the environmental chemical space of the human exposome. Defined as the …
A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability
A Moretton, S Kourtis, A Gañez Zapater… - Molecular Systems …, 2023 - embopress.org
While cellular metabolism impacts the DNA damage response, a systematic understanding
of the metabolic requirements that are crucial for DNA damage repair has yet to be …
of the metabolic requirements that are crucial for DNA damage repair has yet to be …
The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment
IMCM Rietjens, A Michael, HM Bolt, B Siméon… - Archives of …, 2022 - Springer
The “totality” of the human exposure is conceived to encompass life-associated endogenous
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
Interplay between cellular metabolism and the DNA damage response in cancer
Metabolism is a fundamental cellular process that can become harmful for cells by leading to
DNA damage, for instance by an increase in oxidative stress or through the generation of …
DNA damage, for instance by an increase in oxidative stress or through the generation of …
DNA–protein cross-links between abasic DNA damage and mitochondrial transcription factor A (TFAM)
In higher eukaryotic cells, mitochondria are essential organelles for energy production,
metabolism, and signaling. Mitochondrial DNA (mtDNA) encodes 13 protein subunits for …
metabolism, and signaling. Mitochondrial DNA (mtDNA) encodes 13 protein subunits for …