Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle
J Salje - Nature Reviews Microbiology, 2021 - nature.com
The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …
that include many organisms of clinical and agricultural importance, including Anaplasma …
Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses
Scrub typhus and spotted fever rickettsioses (SFR) are understudied, vector-borne diseases
of global significance. Over 1 billion individuals are at risk for scrub typhus alone in an …
of global significance. Over 1 billion individuals are at risk for scrub typhus alone in an …
Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen
B Mika-Gospodorz, S Giengkam… - Nature …, 2020 - nature.com
Studying emerging or neglected pathogens is often challenging due to insufficient
information and absence of genetic tools. Dual RNA-seq provides insights into host …
information and absence of genetic tools. Dual RNA-seq provides insights into host …
Orientia tsutsugamushi selectively stimulates the C-type lectin receptor Mincle and type 1-skewed proinflammatory immune responses
Orientia tsutsugamushi is an obligately intracellular bacterium and the etiological agent of
scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed …
scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed …
Immune response against rickettsiae: lessons from murine infection models
A Osterloh - Medical microbiology and immunology, 2017 - Springer
Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases.
Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly …
Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly …
Vaccine design and vaccination strategies against rickettsiae
A Osterloh - Vaccines, 2021 - mdpi.com
Rickettsioses are febrile, potentially lethal infectious diseases that are a serious health
threat, especially in poor income countries. The causative agents are small obligate …
threat, especially in poor income countries. The causative agents are small obligate …
Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi
Orientia tsutsugamushi is an obligately intracellular bacterium with endothelial tropism and
can cause mild to lethal scrub typhus in humans. No vaccine is available for this reemerging …
can cause mild to lethal scrub typhus in humans. No vaccine is available for this reemerging …
[HTML][HTML] Orientia tsutsugamushi infection stimulates Syk-dependent responses and innate cytosolic defenses in macrophages
Orientia tsutsugamushi is an obligately intracellular bacterium and an etiological agent of
scrub typhus. Human studies and animal models of scrub typhus have shown robust type 1 …
scrub typhus. Human studies and animal models of scrub typhus have shown robust type 1 …
A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses
Despite the various roles of type I interferon (type I IFN) responses during bacterial infection,
its specific effects in vivo have been poorly characterized in scrub typhus caused by Orientia …
its specific effects in vivo have been poorly characterized in scrub typhus caused by Orientia …
An update on host-pathogen interplay and modulation of immune responses during Orientia tsutsugamushi infection
The obligate intracellular bacterium Orientia tsutsugamushi is the causative agent of scrub
typhus in humans, a serious mite-borne disease present in a widespread area of endemicity …
typhus in humans, a serious mite-borne disease present in a widespread area of endemicity …