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Mechanisms of SARS-CoV-2 entry into cells
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …
Immune response, inflammation, and the clinical spectrum of COVID-19
The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …
extended to become a global sanitary and economic emergency. Its etiological agent is the …
The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion …
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion …
Heightened innate immune responses in the respiratory tract of COVID-19 patients
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …
infection have posed a severe threat to global public health. It is unclear how the human …
Interplay between SARS-CoV-2 and the type I interferon response
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
Syncytia formation by SARS‐CoV‐2‐infected cells
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
Bat-borne virus diversity, spillover and emergence
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …
A comprehensive review of viral characteristics, transmission, pathophysiology, immune response, and management of SARS-CoV-2 and COVID-19 as a basis for …
COVID-19 emerged from China in December 2019 and during 2020 spread to every
continent including Antarctica. The coronavirus, SARS-CoV-2, has been identified as the …
continent including Antarctica. The coronavirus, SARS-CoV-2, has been identified as the …
Human coronavirus: host-pathogen interaction
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …