Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?

V Alterio, A Di Fiore, K D'Ambrosio, CT Supuran… - Chemical …, 2012 - ACS Publications
Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging

F Yang, Y Li, Z Chen, Y Zhang, J Wu, N Gu - Biomaterials, 2009 - Elsevier
An encapsulated microbubble (EMB) of a novel construct is proposed to enhance the
magnetic resonance imaging contrast by introducing superparamagnetic iron oxide (SPIO) …

The porcine lung as a potential model for cystic fibrosis

CS Rogers, WM Abraham… - … of Physiology-Lung …, 2008 - journals.physiology.org
Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and develo** …

Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: review of current and emerging translational methods and applications

S Fain, ML Schiebler, DG McCormack… - Journal of magnetic …, 2010 - Wiley Online Library
During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …

The small airways and distal lung compartment in asthma and COPD: a time for reappraisal

M Contoli, J Bousquet, LM Fabbri, H Magnussen… - Allergy, 2010 - Wiley Online Library
To cite this article: Contoli M, Bousquet J, Fabbri LM, Magnussen H, Rabe KF, Siafakas NM,
Hamid Q, Kraft M. The small airways and distal lung compartment in asthma and COPD: a …

In vivo magnetic resonance imaging of hyperpolarized silicon particles

MC Cassidy, HR Chan, BD Ross… - Nature …, 2013 - nature.com
Silicon-based micro-and nanoparticles have gained popularity in a wide range of
biomedical applications due to their biocompatibility and biodegradability in vivo, as well as …

Chronic Obstructive Pulmonary Disease: Safety and Tolerability of Hyperpolarized 129Xe MR Imaging in Healthy Volunteers and Patients

B Driehuys, S Martinez-Jimenez, ZI Cleveland… - Radiology, 2012 - pubs.rsna.org
Purpose To evaluate the safety and tolerability of inhaling multiple 1-L volumes of undiluted
hyperpolarized xenon 129 (129Xe) followed by up to a 16-second breath hold and magnetic …

Functional imaging of the lungs with gas agents

SJ Kruger, SK Nagle, MJ Couch, Y Ohno… - Journal of Magnetic …, 2016 - Wiley Online Library
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

Enabling Clinical Technologies for Hyperpolarized 129Xenon Magnetic Resonance Imaging and Spectroscopy

AS Khan, RL Harvey, JR Birchall… - Angewandte Chemie …, 2021 - Wiley Online Library
Hyperpolarization is a technique that can increase nuclear spin polarization with the
corresponding gains in nuclear magnetic resonance (NMR) signals by 4–8 orders of …