Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …
Peering into tunneling nanotubes—The path forward
D Cordero Cervantes, C Zurzolo - The EMBO journal, 2021 - embopress.org
Abstract The identification of Tunneling Nanotubes (TNTs) and TNT‐like structures signified
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell …
T Hyvärinen, S Hagman, M Ristola, L Sukki, K Veijula… - Scientific reports, 2019 - nature.com
Astrocyte reactivation has been discovered to be an important contributor to several
neurological diseases. In vitro models involving human astrocytes have the potential to …
neurological diseases. In vitro models involving human astrocytes have the potential to …
Advances in microfluidic in vitro systems for neurological disease modeling
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …
death worldwide. Despite significant research efforts, neurology remains one of the most …
In vitro microfluidic models for neurodegenerative disorders
Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Friedreich's ataxia (FRDA) is an autosomal-recessive neurodegenerative and cardiac
disorder which occurs when transcription of the FXN gene is silenced due to an excessive …
disorder which occurs when transcription of the FXN gene is silenced due to an excessive …
Three‐dimensional models of the human brain development and diseases
Deciphering the human brain pathophysiology remains one of the greatest challenges of the
21st century. Neurological disorders represent a significant proportion of diseases burden; …
21st century. Neurological disorders represent a significant proportion of diseases burden; …
3D‐Printed soft lithography for complex compartmentalized microfluidic neural devices
Compartmentalized microfluidic platforms are an invaluable tool in neuroscience research.
However, harnessing the full potential of this technology remains hindered by the lack of a …
However, harnessing the full potential of this technology remains hindered by the lack of a …
Modular microstructure design to build neuronal networks of defined functional connectivity
Theoretical and in vivo neuroscience research suggests that functional information transfer
within neuronal networks is influenced by circuit architecture. Due to the dynamic …
within neuronal networks is influenced by circuit architecture. Due to the dynamic …
Modeling Neurodegenerative Diseases Using In Vitro Compartmentalized Microfluidic Devices
L Miny, BGC Maisonneuve, I Quadrio… - … in Bioengineering and …, 2022 - frontiersin.org
The human brain is a complex organ composed of many different types of cells
interconnected to create an organized system able to efficiently process information …
interconnected to create an organized system able to efficiently process information …