After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Given the ever‐increasing toxic exposure ubiquitously present in our environment as well as
emerging evidence that these exposures are hazardous to human health, the current rodent …

Rationale: The adult human heart is an organ with low regenerative potential. Heart failure
following acute myocardial infarction is a leading cause of death due to the inability of …

In contrast to adult mammals, adult zebrafish can fully regenerate injured cardiac tissue, and
this regeneration process requires an adequate and tightly controlled immune response …

Defective coronary network function and insufficient blood supply are both cause and
consequence of myocardial infarction. Efficient revascularization after infarction is essential …

Damage-induced fibrotic scarring limits tissue regeneration in mammals and is a leading
cause of morbidity. In contrast, species like zebrafish can regenerate damaged tissues …

Myocardial infarction (MI) leads to a severe loss of cardiomyocytes, which in mammals are
replaced by scar tissue. Epicardial derived cells (EPDCs) have been reported to differentiate …

The zebrafish heart regenerates after ventricular damage through a process involving
inflammation, fibrotic tissue deposition/removal and myocardial regeneration. Using 3D …

The evolutionary conservation of genomic, biochemical, and developmental features
between zebrafish and humans is gradually coming into focus, with the end result that the …

The zebrafish Danio rerio, a tropical freshwater fish, belongs to the family of cyprinidae,
which in the last 30 years has developed into a very popular model organism for studies of …