Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Neutrophils are polymorphonuclear leukocytes of the phagocytic system that act as first line
of host defense against invading pathogens but are also important mediators of …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

The multistep sequence leading to leukocyte migration is thought to be locally regulated at
the inflammatory site. Here, we show that broad systemic programs involving long-range …

The migration of neutrophils into inflamed tissues is a fundamental component of innate
immunity. A decisive step in this process is the polarized migration of blood neutrophils …

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

Endothelial cells line the lumen of all blood vessels and play a critical role in maintaining the
barrier function of the vasculature. Sealing of the vessel wall between adjacent endothelial …

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the
vascular lumen to the extravascular tissue, but fundamental aspects of this response remain …

Neutrophil migration to injured and pathogen-infected tissues is a fundamental component
of innate immunity. An array of cellular and molecular events mediate this response to …

Reperfusion injury following ischemic stroke is a complex pathophysiological process
involving numerous mechanisms ranging from the release of excitatory amino acids and ion …