Although many kinds of therapies are applied in the clinic, drug-resistance is a major and
unavoidable problem. Another disturbing statistic is the limited number of drug targets, which …

Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-
renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero.
This lineage is specified before implantation into the uterus and is restricted to form the fetal …

Life begins with a switch in genetic control from the maternal to the embryonic genome
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …

The placenta is the first organ to form during mammalian embryogenesis. Problems in its
formation and function underlie many aspects of early pregnancy loss and pregnancy …

Blastocyst formation marks the segregation of the first two cell lineages in the mammalian
preimplantation embryo: the inner cell mass (ICM) that will form the embryo proper and the …

Large-scale phenoty** efforts have demonstrated that approximately 25–30% of mouse
gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused …

We present an integrated approach to identify genetic mechanisms that control self-renewal
in mouse embryonic stem cells. We use short hairpin RNA (shRNA) loss-of-function …