How the extracellular matrix shapes neural development

KR Long, WB Huttner - Royal Society Open Biology, 2019 - royalsocietypublishing.org
During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

Drosophila glia: Few cell types and many conserved functions

K Yildirim, J Petri, R Kottmeier, C Klämbt - Glia, 2019 - Wiley Online Library
Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

R Jayadev, MRPT Morais, JM Ellingford… - Science …, 2022 - science.org
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By develo** a …

A gene-specific T2A-GAL4 library for Drosophila

PT Lee, J Zirin, O Kanca, WW Lin, KL Schulze… - elife, 2018 - elifesciences.org
We generated a library of~ 1000 Drosophila stocks in which we inserted a construct in the
intron of genes allowing expression of GAL4 under control of endogenous promoters while …

Basement membrane dynamics and mechanics in tissue morphogenesis

U Töpfer - Biology Open, 2023 - journals.biologists.com
The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies
epithelia and surrounds most organs. During development, the BM is highly dynamic and …

Glia as functional barriers and signaling intermediaries

VM Fernandes, V Auld… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Glia play a crucial role in providing metabolic support to neurons across different species. To
do so, glial cells isolate distinct neuronal compartments from systemic signals and …

Basement membrane remodeling guides cell migration and cell morphogenesis during development

DR Sherwood - Current opinion in cell biology, 2021 - Elsevier
Basement membranes (BMs) are thin, dense forms of extracellular matrix that underlie or
surround most animal tissues. BMs are enormously complex and harbor numerous proteins …

Social reprogramming in ants induces longevity-associated glia remodeling

L Sheng, EJ Shields, J Gospocic, KM Glastad… - Science …, 2020 - science.org
In social insects, workers and queens arise from the same genome but display profound
differences in behavior and longevity. In Harpegnathos saltator ants, adult workers can …

Drosophila glia take shape to sculpt the nervous system

MM Corty, J Coutinho-Budd - Current opinion in neurobiology, 2023 - Elsevier
The importance of glial cells has become increasingly apparent over the past 20 years, yet
compared to neurons we still know relatively little about these essential cells. Most critical …

Basement membrane mechanics shape development: Lessons from the fly

W Ramos-Lewis, A Page-McCaw - Matrix Biology, 2019 - Elsevier
Basement membrane plays a foundational role in the structure and maintenance of many
tissues throughout the animal kingdom. In addition to signaling to cells through cell-surface …