Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Macrophages are crucial cells in the human body's innate immunity and are engaged in a
variety of non-inflammatory reactions. Macrophages can develop into two kinds when …

Macrophages are important components of the immune system. Mature macrophages can
be recruited to tumor microenvironment that affect tumor cell proliferation, invasion and …

Osteoarthritis (OA) is a chronic joint disease characterized by synovitis and joint cartilage
destruction. The severity of OA is highly associated with the imbalance between M1 and M2 …

Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the
exploration of additional pathogenic factors and the development of new therapeutics are …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent
synovial inflammation and progressive joint destruction. Macrophages are key effector cells …