For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

In ophthalmic research, there is a strong need for in vitro models of the neuroretina. Here,
we present a detailed protocol for organotypic culturing of the mouse neuroretina with intact …

Programmed cell death (PCD) is a highly regulated process that results in the orderly
destruction of a cell. Many different forms of PCD may be distinguished, including apoptosis …

Inherited retinal degenerative diseases (IRDs), which ultimately lead to photoreceptor cell
death, are characterized by high genetic heterogeneity. Many IRD-associated genetic …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood. The aim of this study was to systematically map the transcriptional changes that …

Therapy development for neurodegenerative diseases of the retina constitutes a major
unmet medical need, and this may be particularly relevant for inherited diseases of the …

Bioengineering systems have transformed scientific knowledge of cellular behaviors in the
nervous system (NS) and pioneered innovative, regenerative therapies to treat adult neural …

Retinal pathologies are major causes of vision impairment and blindness in humans, and
inherited retinal diseases (IRDs), such as retinitis pigmentosa, Leber congenital amaurosis …

Hereditary retinal degeneration (RD) is characterized by progressive photoreceptor cell
death. Overactivation of the cyclic guanosine monophosphate (cGMP)-dependent protein …