Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix,
behaving as a critical mechanism in preventing adherent-independent cell growth and …

The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining
feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Proinflammatory cytokines produced in the tumor microenvironment facilitate tumor
development and metastatic progression. In particular, TNF-α promotes cancer invasion and …

This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

Cancer metastasis consists of a sequential series of events, and the epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) are recognized …

Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …

Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use
to eliminate 'misplaced'cells, ie cells that are in an inappropriate location. Occasionally …