Voltage-gated ion channels and hereditary disease

F Lehmann-Horn, K Jurkat-Rott - Physiological reviews, 1999 - journals.physiology.org
By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

Progress in reducing the pale, soft and exudative (PSE) problem in pork and poultry meat

S Barbut, AA Sosnicki, SM Lonergan, T Knapp… - Meat science, 2008 - Elsevier
Research in the area of the pale, soft and exudative (PSE) pork and poultry meat is reviewed
in this article with an emphasis on genetic, biochemical and metabolic factors contributing to …

Chicken meat quality: genetic variability and relationship with growth and muscle characteristics

E Le Bihan-Duval, M Debut, CM Berri, N Sellier… - BMC genetics, 2008 - Springer
Background The qualitative properties of the meat are of major importance for poultry
breeding, since meat is now widely consumed as cuts or as processed products. The aim of …

A mutation in the human ryanodine receptor gene associated with central core disease

Y Zhang, HS Chen, VK Khanna, S De Leon… - Nature …, 1993 - nature.com
Central core disease (CCD) is a morphologically distinct, autosomal dominant myopathy
with variable clinical features. A close association with malignant hypertheria (MH) has been …

A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia

EF Gillard, K Otsu, J Fujii, VK Khanna, S de Leon… - Genomics, 1991 - Elsevier
Malignant hyperthermia (MH) is a devastating, potentially lethal response to anesthetics that
occurs in genetically predisposed individuals. The skeletal muscle ryanodine receptor …

T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases

L Al-Qusairi, J Laporte - Skeletal muscle, 2011 - Springer
In skeletal muscle, the excitation-contraction (EC) coupling machinery mediates the
translation of the action potential transmitted by the nerve into intracellular calcium release …

Genetics and pathogenesis of malignant hyperthermia

K Jurkat‐Rott, T McCarthy… - Muscle & Nerve: Official …, 2000 - Wiley Online Library
Malignant hyperthermia (MH) is a potentially life‐threatening event in response to anesthetic
triggering agents, with symptoms of sustained uncontrolled skeletal muscle calcium …

Role of ryanodine receptors

Y Ogawa - Critical Reviews in Biochemistry and Molecular Biology, 1994 - Taylor & Francis
Recent findings on the ryanodine receptor of vertebrates, a Ca-release channel protein for
the caffeine-and ryanodine-sensitive Ca pools, are reviewed in this article. Three distinct …

Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects

JR Mickelson, CF Louis - Physiological Reviews, 1996 - journals.physiology.org
Malignant hyperthermia (MH) is a disorder of skeletal muscle in which certain anesthetic
agents trigger a sustained elevation in myoplasmic Ca2+ concentration that activates …

The growth performance, carcass characteristics, and meat quality of halothane carrier and negative pigs

LM Leach, M Ellis, DS Sutton, FK McKeith… - Journal of Animal …, 1996 - academic.oup.com
Growth performance, carcass characteristics, and meat quality of halothane carrier (Nn) and
negative (NN) pigs grown from 40 kg live weight and slaughtered at three weights (110, 125 …