Neurogenesis in the aging brain

DM Apple, R Solano-Fonseca, E Kokovay - Biochemical pharmacology, 2017 - Elsevier
Adult neurogenesis is the process of producing new neurons from neural stem cells (NSCs)
for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular …

Multiple effects of growth hormone in the body: is it really the hormone for growth?

J Devesa, C Almengló… - Clinical Medicine Insights …, 2016 - journals.sagepub.com
In this review, we analyze the effects of growth hormone on a number of tissues and organs
and its putative role in the longitudinal growth of an organism. We conclude that the …

Neurogenesis in the normal ageing hippocampus: a mini-review

DRM Seib, A Martin-Villalba - Gerontology, 2015 - karger.com
New neurons are continuously generated and added to neural circuits in the adult brain.
However, increasing age imposes changes in neural progenitor cells and their …

Mechanisms of enhanced quiescence in neural stem cell aging

AJ Audesse, AE Webb - Mechanisms of ageing and development, 2020 - Elsevier
The maintenance of neural stem cell function is vital to ensure neurogenesis throughout
adulthood. During aging, there is a significant reduction in adult neurogenesis that …

Lasting adaptations in social behavior produced by social disruption and inhibition of adult neurogenesis

M Opendak, L Offit, P Monari, TJ Schoenfeld… - Journal of …, 2016 - jneurosci.org
Research on social instability has focused on its detrimental consequences, but most people
are resilient and respond by invoking various co** strategies. To investigate cellular …

New neurons in aging brains: molecular control by small non-coding RNAs

M Schouten, MR Bui**k, PJ Lucassen… - Frontiers in …, 2012 - frontiersin.org
Adult neurogenesis generates functional neurons from neural stem cells present in specific
brain regions. It is largely confined to two main regions: the subventricular zone of the lateral …

Exercise and environment as an intervention for neonatal alcohol effects on hippocampal adult neurogenesis and learning

GF Hamilton, SA Jablonski, FL Schiffino, SAS Cyr… - Neuroscience, 2014 - Elsevier
Neonatal alcohol exposure impairs cognition and learning in adulthood and permanently
damages the hippocampus. Wheel running (WR) improves hippocampus-associated …

Distinguishing adaptive plasticity from vulnerability in the aging hippocampus

DT Gray, CA Barnes - Neuroscience, 2015 - Elsevier
Hippocampal circuits are among the best described networks in the mammalian brain,
particularly with regard to the alterations that arise during normal aging. Decades of …

Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus

P Mishra, R Narayanan - Journal of neurophysiology, 2020 - journals.physiology.org
The dentate gyrus (DG), the input gate to the hippocampus proper, is anatomically
segregated into three different sectors, namely, the suprapyramidal blade, the crest region …

Effect of Nrf2 loss on senescence and cognition of tau-based P301S mice

R Riordan, W Rong, Z Yu, G Ross, J Valerio… - Geroscience, 2023 - Springer
Cellular senescence may contribute to chronic inflammation involved in the progression of
age-related diseases such as Alzheimer's disease (AD), and its removal prevents cognitive …