Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …

INTRODUCTION Resident tissue macrophages (RTMs) are a heterogeneous population of
immune cells occupying multiple tissue niches and exhibiting microenvironment-specific …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

The skin is the outermost organ of the body and is continuously exposed to external
pathogens. Upon inflammation, various immune cells pass through, reside in or are …

Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …

Innate immune cells recruited to inflammatory sites have short life spans and originate from
the marrow, which is distributed throughout the long and flat bones. While bone marrow …

Macrophages are present in all tissues, either as resident cells or monocyte-derived cells
that infiltrate into tissues. The tissue site largely determines the phenotype of tissue-resident …