Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

Ubiquitylation is essential for signal transduction as well as cell division and differentiation in
all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …