Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies

X Zhang, J Wang, Z Zhang, K Ye - Translational Neurodegeneration, 2024 - Springer
The deposition of abnormal tau protein is characteristic of Alzheimer's disease (AD) and a
class of neurodegenerative diseases called tauopathies. Physiologically, tau maintains an …

[HTML][HTML] White matter damage and degeneration in traumatic brain injury

RC Armstrong, GM Sullivan, DP Perl, JD Rosarda… - Trends in …, 2024 - cell.com
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

Neuropathologic and clinical findings in young contact sport athletes exposed to repetitive head impacts

AC McKee, J Mez, B Abdolmohammadi… - JAMA …, 2023 - jamanetwork.com
Importance Young contact sport athletes may be at risk for long-term neuropathologic
disorders, including chronic traumatic encephalopathy (CTE). Objective To characterize the …

Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career

W Stewart, ME Buckland, B Abdolmohammadi… - Acta …, 2023 - Springer
There is concern over late, adverse brain health outcomes associated with contact sports
participation, with high neurodegenerative disease risk reported in studies of former …

Update on modifiable risk factors for Alzheimer's disease and related dementias

M Jaisa-Aad, C Muñoz-Castro… - Current Opinion in …, 2024 - journals.lww.com
While greater and higher quality epidemiological and experimental evidence is needed to
unequivocally confirm their causal link with ADRD and/or unravel the underlying …

Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

Z Huang, P Xu, DC Hess, Q Zhang - Translational Neurodegeneration, 2024 - Springer
Traumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of
individuals globally. Once considered solely acute events, these neurological conditions are …

A review of brain regions and associated post-concussion symptoms

E Danielli, N Simard, CA DeMatteo… - Frontiers in …, 2023 - frontiersin.org
The human brain is an exceptionally complex organ that is comprised of billions of neurons.
Therefore, when a traumatic event such as a concussion occurs, somatic, cognitive …

Alzheimer's Disease-Related Dementias Summit 2022: national research priorities for the investigation of post-traumatic brain injury Alzheimer's disease and related …

K Dams-O'Connor, HO Awwad, S Hoffman… - Journal of …, 2023 - liebertpub.com
Traumatic Brain Injury (TBI) is a risk factor for Alzheimer's disease and Alzheimer's disease
related dementias (AD/ADRD) and otherwise classified post-traumatic neurodegeneration …

Chronic traumatic encephalopathy in a female ex-professional Australian rules footballer

CM Suter, AJ Affleck, AJ Pearce, R Junckerstorff… - Acta …, 2023 - Springer
Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis of degenerative
brain disease characterized by neuronal accumulation of hyperphosphorylated tau (p-tau) …

Innovative insights into traumatic brain injuries: biomarkers and new pharmacological targets

S Silvestro, I Raffaele, A Quartarone… - International Journal of …, 2024 - mdpi.com
A traumatic brain injury (TBI) is a major health issue affecting many people across the world,
causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting …