[HTML][HTML] Modeling Viral Capsid Assembly: A Review of Computational Strategies and Applications

W Guo, E Alarcon, JE Sanchez, C **ao, L Li - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Viral capsid assembly is a complex and critical process, essential for understanding viral
behavior, evolution, and the development of antiviral treatments, vaccines, and …

The pH effects on SARS-CoV and SARS-CoV-2 spike proteins in the process of binding to hACE2

Y **e, W Guo, A Lopez-Hernadez, S Teng, L Li - Pathogens, 2022 - mdpi.com
COVID-19 has been threatening human health since the late 2019, and has a significant
impact on human health and economy. Understanding SARS-CoV-2 and other …

A comprehensive study on the electrostatic properties of tubulin-tubulin complexes in microtubules

W Guo, TA Ale, S Sun, JE Sanchez, L Li - Cells, 2023 - mdpi.com
Microtubules are key players in several stages of the cell cycle and are also involved in the
transportation of cellular organelles. Microtubules are polymerized by α/β tubulin dimers with …

[HTML][HTML] A comparative analysis of sars-cov-2 variants of concern (voc) spike proteins interacting with hace2 enzyme

J Chen, L Chen, H Quan, S Lee, KF Khan… - International journal of …, 2024 - mdpi.com
In late 2019, the emergence of a novel coronavirus led to its identification as SARS-CoV-2,
precipitating the onset of the COVID-19 pandemic. Many experimental and computational …

[HTML][HTML] Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule

W Guo, S Sun, JE Sanchez… - Computational and …, 2022 - Elsevier
Kinesins are microtubule-based motor proteins that play important roles ranging from
intracellular transport to cell division. Human Kinesin-5 (Eg5) is essential for mitotic spindle …

Bound ion effects: Using machine learning method to study the kinesin Ncd's binding with microtubule

W Guo, D Du, H Zhang, JE Sanchez, S Sun, W Xu… - Biophysical journal, 2024 - cell.com
Drosophila Ncd proteins are motor proteins that play important roles in spindle organization.
Ncd and the tubulin dimer are highly charged. Thus, it is crucial to investigate Ncd-tubulin …

Computational study on DNA repair: The roles of electrostatic interactions between uracil-DNA glycosylase (UDG) and DNA

Y **e, CB Karki, J Chen, D Liu, L Li - Frontiers in Molecular …, 2021 - frontiersin.org
Uracil-DNA glycosylase (UDG) is one of the most important base excision repair (BER)
enzymes involved in the repair of uracil-induced DNA lesion by removing uracil from the …

[HTML][HTML] HIT web server: A hybrid method to improve electrostatic calculations for biomolecules

S Sun, JA Lopez, Y **e, W Guo, D Liu, L Li - Computational and Structural …, 2022 - Elsevier
The electrostatic features of highly charged biomolecules are crucial and challenging tasks
in computational biophysics. The electrostatic calculations by traditional implicit solvent …

Nanotechnology-Based Modern Biosensors for the Detection of SARS-CoV-2 Virus

S Devi, N Yadav, R Yadav - Indian Journal of Microbiology, 2024 - Springer
The emergence of the COVID-19 pandemic has pointed out the urgent need for rapid and
accurate diagnostic tools to detect the SARS-CoV-2 virus. Nanotechnology-based …

Local Microenvironments of capsomer variants in the PBCV-1

W Guo, E Alarcon, JE Sanchez, C **ao, L Li - bioRxiv, 2025 - biorxiv.org
PBCV-1, a giant virus classified among the Nucleocytoviricota virus (NCV) whose structure
has been determined to near atomic resolution. The majority capsomers forming the capsid …