[PDF][PDF] One year in review 2020: pathogenesis of rheumatoid arthritis

D Giannini, M Antonucci, F Petrelli, S Bilia… - Clin Exp …, 2020 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both
genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms …

Mouse Models and Tools for the in vivo Study of Neutrophils

J Stackowicz, F Jönsson, LL Reber - Frontiers in immunology, 2020 - frontiersin.org
Neutrophils are the most abundant leukocytes in human blood and critical actors of the
immune system. Many neutrophil functions and facets of their activity in vivo were revealed …

A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis

Y He, C Ge, À Moreno-Giró, B Xu, CM Beusch… - Nature …, 2023 - nature.com
Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …

Polystyrene microplastics-induced macrophage extracellular traps contributes to liver fibrotic injury by activating ROS/TGF-β/Smad2/3 signaling axis

S Wang, L Chen, X Shi, Y Wang, S Xu - Environmental Pollution, 2023 - Elsevier
Microplastics (MPs) are a type of emerging pollutant, posing a great threat to human and
animal health. While recent studies have revealed the link between MPs exposure and liver …

Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

M Zhai, S Gong, P Luan, Y Shi, W Kou, Y Zeng… - Nature …, 2022 - nature.com
Extracellular DNA traps (ETs) represent an immune response by which cells release
essential materials like chromatin and granular proteins. Previous studies have …

Citrullinated histone H3 as a therapeutic target for endotoxic shock in mice

Q Deng, B Pan, HB Alam, Y Liang, Z Wu, B Liu… - Frontiers in …, 2020 - frontiersin.org
Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the
leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are …

[HTML][HTML] The role of pancreatic infiltrating innate immune cells in acute pancreatitis

C Peng, Z Li, X Yu - International journal of medical sciences, 2021 - ncbi.nlm.nih.gov
Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions
with significant morbidity and mortality. Although the underlying pathophysiology of AP is …

Advancements in rheumatoid arthritis therapy: a journey from conventional therapy to precision medicine via nanoparticles targeting immune cells

A Laha, S Nasra, D Bhatia, A Kumar - Nanoscale, 2024 - pubs.rsc.org
Rheumatoid arthritis (RA) is a progressive autoimmune disease that mainly affects the inner
lining of the synovial joints and leads to chronic inflammation. While RA is not known as …

Citrullination and PAD enzyme biology in type 1 diabetes–regulators of inflammation, autoimmunity, and pathology

ML Yang, FMC Sodré, MJ Mamula… - Frontiers in …, 2021 - frontiersin.org
The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

Macrophage extracellular traps promote tumor-like biologic behaviors of fibroblast-like synoviocytes through cGAS-mediated PI3K/Akt signaling pathway in patients …

W Weng, Y Liu, Z Hu, Z Li, X Peng… - Journal of Leukocyte …, 2024 - academic.oup.com
Rheumatoid arthritis is an autoimmune disease characterized by synovium hyperplasia and
bone destruction. Macrophage extracellular traps are released from macrophages under …