Beyond heat stress: intestinal integrity disruption and mechanism-based intervention strategies

P Lian, S Braber, J Garssen, HJ Wichers, G Folkerts… - Nutrients, 2020 - mdpi.com
The current climate changes have increased the prevalence and intensity of heat stress (HS)
conditions. One of the initial consequences of HS is the impairment of the intestinal epithelial …

Exertional heat stroke: nutritional considerations

JKW Lee, B Tan, HB Ogden, S Chapman… - Experimental …, 2022 - Wiley Online Library
New Findings What is the topic of this review? The potential role of nutrition in exertional
heat stroke. What advances does it highlight? Certain nutritional and dietary strategies used …

Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke

WC Lee, HC Wen, CP Chang… - Journal of applied …, 2006 - journals.physiology.org
This study extends our earlier studies in rats by applying our heatstroke model to a new
species. Additionally, transgenic mice are used to examine the role of heat shock protein …

Ischemic and oxidative damage to the hypothalamus may be responsible for heat stroke

SH Chen, MT Lin, CP Chang - Current Neuropharmacology, 2013 - ingentaconnect.com
The hypothalamus may be involved in regulating homeostasis, motivation, and emotional
behavior by controlling autonomic and endocrine activity. The hypothalamus communicates …

Nutritional considerations to counteract gastrointestinal permeability during exertional heat stress

MA King, I Rollo, LB Baker - Journal of applied physiology, 2021 - journals.physiology.org
Intestinal barrier integrity and function are compromised during exertional heat stress (EHS)
potentially leading to consequences that range from minor gastrointestinal (GI) disturbances …

Unravelling the impacts of climatic heat events on cardiovascular health in animal models

N Mol, A Priya, AK Singh, P Mago, AK Ray - Environmental Research, 2024 - Elsevier
Climate change has led to an increase in high ambient temperatures, causing extreme heat
events worldwide. According to the World Meteorological Organization (WMO), July 2023 …

Protective effects of hyperbaric oxygen therapy on brain injury by regulating the phosphorylation of Drp1 through ROS/PKC pathway in heatstroke rats

X Ni, J Nie, Q **e, R Yu, L Su, Z Liu - Cellular and Molecular Neurobiology, 2020 - Springer
This study aimed to elucidate the neurotherapeutic effect of hyperbaric oxygen (HBO) on
brain injury and the potential role of dynamin-related protein 1 (Drp1) and its regulatory …

[HTML][HTML] JAK2/STAT3 pathway mediating inflammatory responses in heatstroke-induced rats

Z Tao, M Cheng, SC Wang, W Lv, HQ Hu… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Heatstroke not only directly induces cell injury, but also causes large amounts of
inflammatory mediators release and cells with extensive biological activities to induce a …

Dexmedetomidine protects against multi-organ dysfunction induced by heatstroke via sustaining the intestinal integrity

ZN **a, Y Zong, ZT Zhang, JK Chen, XJ Ma, YG Liu… - Shock, 2017 - journals.lww.com
Previous studies have indicated that gut-derived endotoxin played a pivotal role for
aggravating systemic inflammatory response to multi-organ dysfunction under heatstroke …

The adverse effect of heat stress and potential nutritional interventions

X Chen, W Liu, H Li, J Zhang, C Hu, X Liu - Food & Function, 2022 - pubs.rsc.org
Heat stress can cause tissue damage and metabolic disturbances, including intestinal and
liver dysfunction, acid–base imbalance, oxidative damage, inflammatory response, and …