Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
T Muramatsu - Proceedings of the Japan Academy, Series B, 2010 - jstage.jst.go.jp
Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa.
Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The …
Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The …
Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases
DR Jones - British journal of pharmacology, 2014 - Wiley Online Library
Midkine (MK) is a pleiotropic growth factor prominently expressed during embryogenesis but
down‐regulated to neglible levels in healthy adults. Many published studies have …
down‐regulated to neglible levels in healthy adults. Many published studies have …
Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives
G Herradón, C Pérez‐García - British journal of pharmacology, 2014 - Wiley Online Library
Midkine (MK) and pleiotrophin (PTN) are two neurotrophic factors that are highly up‐
regulated in different brain regions after the administration of various drugs of abuse and in …
regulated in different brain regions after the administration of various drugs of abuse and in …
Midkine: a promising molecule for drug development to treat diseases of the central nervous system
T Muramatsu - Current pharmaceutical design, 2011 - ingentaconnect.com
Midkine (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and
other activities of target cells. After describing the general properties of MK, this review …
other activities of target cells. After describing the general properties of MK, this review …
Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death
V Soura, M Stewart-Parker, TL Williams… - Biochemical …, 2012 - portlandpress.com
Aβ42 [amyloid-β peptide-(1–42)] plays a central role in Alzheimer's disease and is known to
have a detrimental effect on neuronal cell function and survival when assembled into an …
have a detrimental effect on neuronal cell function and survival when assembled into an …
The role of midkine in health and disease
EE Neumaier, V Rothhammer… - Frontiers in …, 2023 - frontiersin.org
Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with
important functions related to growth, proliferation, survival, migration, angiogenesis …
important functions related to growth, proliferation, survival, migration, angiogenesis …
Midkine: a novel prognostic biomarker for cancer
H Jono, Y Ando - Cancers, 2010 - mdpi.com
Since diagnosis at an early stage still remains a key issue for modern oncology and is
crucial for successful cancer therapy, development of sensitive, specific, and non-invasive …
crucial for successful cancer therapy, development of sensitive, specific, and non-invasive …
Glycosaminoglycan‐binding cytokines as tumor markers
T Muramatsu, H Muramatsu - Proteomics, 2008 - Wiley Online Library
A significant proportion of cytokines bind to glycosaminoglycans such as heparin.
Glycosaminoglycans are involved in signaling, stabilization and/or storage of these …
Glycosaminoglycans are involved in signaling, stabilization and/or storage of these …
Midkine as a prognostic biomarker in oral squamous cell carcinoma
The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic
tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK …
tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK …
Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis
The aims of this study were to investigate midkine (MK) expression patterns in salivary gland
tumors (SGTs) and to evaluate the correlation between MK expression and the degree of …
tumors (SGTs) and to evaluate the correlation between MK expression and the degree of …