Single-molecule FRET for probing nanoscale biomolecular dynamics
Single-molecule spectroscopy is a powerful method for studying the physics of molecular
systems, particularly biomolecules, such as proteins and nucleic acids. By avoiding …
systems, particularly biomolecules, such as proteins and nucleic acids. By avoiding …
Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: from scattering and spectroscopy to nanoindentation and nanodevices
Exosomes (EXOs) are nano-sized vesicles secreted by most cell types. They are abundant
in bio-fluids and harbor specific molecular constituents from their parental cells. Due to these …
in bio-fluids and harbor specific molecular constituents from their parental cells. Due to these …
Structural heterogeneity of the ion and lipid channel TMEM16F
Z Ye, N Galvanetto, L Puppulin, S Pifferi… - Nature …, 2024 - nature.com
Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …
functions as an ion channel and a phospholipid scramblase. Despite the availability of …
Application of self-organizing maps to AFM-based viscoelastic characterization of breast cancer cell mechanics
Cell mechanical properties have been proposed as label free markers for diagnostic
purposes in diseases such as cancer. Cancer cells show altered mechanical phenotypes …
purposes in diseases such as cancer. Cancer cells show altered mechanical phenotypes …
Advancing High-Throughput Cellular Atomic Force Microscopy with Automation and Artificial Intelligence
Atomic force microscopy (AFM) has reached a significant level of maturity in biology,
demonstrated by the diversity of modes for obtaining not only topographical images but also …
demonstrated by the diversity of modes for obtaining not only topographical images but also …
Iterative Machine Learning for Classification and Discovery of Single-Molecule Unfolding Trajectories from Force Spectroscopy Data
We report the application of machine learning techniques to expedite classification and
analysis of protein unfolding trajectories from force spectroscopy data. Using kernel …
analysis of protein unfolding trajectories from force spectroscopy data. Using kernel …
[HTML][HTML] Nanomechanical Characterization of Soft Nanomaterial Using Atomic Force Microscopy
DL Chi, S Park - Materials Today Bio, 2025 - Elsevier
Atomic force microscopy (AFM) is a promising method for generating high-spatial-resolution
images, providing insightful perspectives on the nanomechanical attributes of soft matter …
images, providing insightful perspectives on the nanomechanical attributes of soft matter …
Unfolding and identification of membrane proteins in situ
Single-molecule force spectroscopy (SMFS) uses the cantilever tip of an atomic force
microscope (AFM) to apply a force able to unfold a single protein. The obtained force …
microscope (AFM) to apply a force able to unfold a single protein. The obtained force …
Unfolding and identification of membrane proteins in situ
G Nicola, Y Zhongjie, M Arin, M Simone, M Sourav… - eLife, 2022 - search.proquest.com
Single-molecule force spectroscopy (SMFS) uses the cantilever tip of an atomic force
microscope (AFM) to apply a force able to unfold a single protein. The obtained force …
microscope (AFM) to apply a force able to unfold a single protein. The obtained force …
Biophysical exploration of membrane-protein interactions in Alzheimer's Disease
A Karkisaval Ganapati - 2023 - escholarship.org
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of
people worldwide and the number is projected to rapidly increase in the coming years. AD …
people worldwide and the number is projected to rapidly increase in the coming years. AD …