[HTML][HTML] State-of the-art constraint-based modeling of microbial metabolism: from basics to context-specific models with a focus on methanotrophs

MA Kulyashov, SK Kolmykov, TM Khlebodarova… - Microorganisms, 2023 - mdpi.com
Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas,
methane, as a source of energy-rich carbon. Over the years, significant progress has been …

Uncovering the effect of sars-cov-2 on liver metabolism via genome-scale metabolic modeling for reprogramming and therapeutic strategies

M Sertbas, KO Ulgen - ACS omega, 2024 - ACS Publications
Genome-scale metabolic models (GEMs) are promising computational tools that contribute
to elucidating host–virus interactions at the system level and develo** therapeutic …

Fuzzy optimization for identifying antiviral targets for treating SARS-CoV-2 infection in the heart

SW Chu, FS Wang - BMC bioinformatics, 2023 - Springer
In this paper, a fuzzy hierarchical optimization framework is proposed for identifying potential
antiviral targets for treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Computational modelling in health and disease: highlights of the 6th annual SysMod meeting

A Niarakis, J Thakar, M Barberis, M Rodríguez Martínez… - 2022 - academic.oup.com
Abstract Summary The Community of Special Interest (COSI) in Computational Modelling of
Biological Systems (SysMod) brings together interdisciplinary scientists interested in …

Understanding disease-associated metabolic changes in human colon epithelial cells using iColonEpithelium metabolic reconstruction

B Jiang, N Quinn-Bohmann, C Diener, VB Nathan… - bioRxiv, 2024 - biorxiv.org
The colon epithelium plays a key role in the host-microbiome interactions, allowing uptake of
various nutrients and driving important metabolic processes. To unravel detailed metabolic …