Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Role of prostaglandin E2 in tissue repair and regeneration

H Cheng, H Huang, Z Guo, Y Chang, Z Li - Theranostics, 2021 - pmc.ncbi.nlm.nih.gov
Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

Immunogenicity of extracellular vesicles

Y **a, J Zhang, G Liu, J Wolfram - Advanced Materials, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery
systems due to demonstrated safety and efficacy in preclinical models and early‐stage …

[HTML][HTML] Exosome nanovesicles: a potential carrier for therapeutic delivery

VP Chavda, A Pandya, L Kumar, N Raval, LK Vora… - Nano Today, 2023 - Elsevier
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the
plasma membrane fuse and are released into the surrounding body fluids. They are best …

Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA

M Zhao, S Liu, C Wang, Y Wang, M Wan, F Liu… - ACS …, 2020 - ACS Publications
Mitochondrial dysfunction is a key feature of injury to numerous tissues and stem cell aging.
Although the tissue regenerative role of mesenchymal stem cell (MSC)-derived extracellular …

Noncancerous disease-targeting AIEgens

Y Duo, G Luo, W Zhang, R Wang, GG **ao… - Chemical Society …, 2023 - pubs.rsc.org
Noncancerous diseases include a wide plethora of medical conditions beyond cancer and
are a major cause of mortality around the world. Despite progresses in clinical research …

Revitalizing ancient mitochondria with nano‐strategies: mitochondria‐remedying nanodrugs concentrate on disease control

X Long, M Liu, Y Nan, Q Chen, Z **ao… - Advanced …, 2024 - Wiley Online Library
Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived …

VVT Nguyen, S Ye, V Gkouzioti… - Journal of …, 2022 - Wiley Online Library
Mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs) show
therapeutic potential in multiple disease models, including kidney injury. Clinical translation …

Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO-1 axis in macrophages

K Shen, Y Jia, X Wang, J Zhang, K Liu, J Wang… - Free Radical Biology …, 2021 - Elsevier
ADSCs exosomes, an important means of intercellular communication, can regulate an
array of biological processes, including promoting tissue repairs and regeneration, and …