Metastasis represents a major obstacle in cancer treatment and the leading cause of cancer-
related deaths. Therefore, the identification of compounds targeting the multi-step and …

Triple-negative breast cancer (TNBC) is the most aggressive type of cancer, with a high risk
of death on recurrence. To date, there is a lack of approved targeted agents for the treatment …

Breast cancer is the leading cause of death among women worldwide. Over the years,
oxidative stress has been linked to the onset and progression of cancer. In addition to the …

Bexarotene (BEX), a specific retinoic acid X receptor (RXR) agonist granted by Food and
Drug Administration (FDA) approval for the clinical treatment of T cell lymphoma, has now …

Abstract 'De novo'drug discovery is costly, slow, and with high risk. Repurposing known
drugs for treatment of other diseases offers a fast, low-cost/risk and highly-efficient method …

Breast cancer remains a leading cause of mortality among women worldwide, with drug
resistance driven by transcription factors and mutations posing significant challenges. To …

Alkamides, or alkylamides, are fatty acid amides produced by plants from the genera
Echinacea, Acmella, Spilanthes, and Heliopsis among others. Alkamides contain varying …

Breast cancer is a complex disease that can be classified into at least 10 different molecular
subtypes. Appropriate diagnosis of specific subtypes is critical for ensuring the best possible …

Background: The importance of amino acid metabolism in multiple cancers was investigated
by accumulating researches. But the role of amino acid metabolism-related genes …

Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), play critical roles in
the resistance to anti-cancer therapies, tumor metastasis and tumor relapse. An innovative …