The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address
limitations of traditional mental disorder diagnoses. These include arbitrary boundaries …

Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Importance Past studies have identified associations between brain macrostructure and
alcohol use behaviors. However, identifying directional associations between these …

Magnetic resonance (MR) techniques provide opportunities to non-invasively characterize
neurobiological milestones of adolescent brain development. Juxtaposed to the critical …

Emerging evidence suggests distinct neurobiological correlates of alcohol use disorder
(AUD) between sexes, which however remain largely unexplored. This work from ENIGMA …

Background Individuals with a family history of alcoholism are at much greater risk for
develo** an alcohol use disorder (AUD) than youth or adults without such history. A large …

Background and aims Cognitive impairment has been associated with excessive alcohol
use, but its neural basis is poorly understood. Chronic excessive alcohol use in adolescence …

Background Alcohol use has been reliably associated with smaller subcortical and cortical
regional gray matter volumes (GMVs). Whether these associations reflect shared …

Identifying associations between interindividual variability in brain structure and behaviour
requires large cohorts, multivariate methods, out-of-sample validation and, ideally, out-of …

Descriptions of the cognitive functions affected by alcohol use disorders (AUD) often
highlight dysfunction of executive processes such attention, inhibitory control, working …