Background Responses to conventional donor lymphocyte infusion for postallogeneic
hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell …

Following T cell receptor triggering, T cell activation is initiated and amplified by the
assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate …

In epithelial-derived cancers, altered regulation of cell–cell adhesion facilitates the
disruption of tissue cohesion that is central to the progression to malignant disease …

CD6 was established as a marker of T cells more than three decades ago, and recent
studies have identified CD6 as a risk gene for multiple sclerosis (MS), a disease in which …

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
recent outbreak of coronavirus disease (COVID-19). In Cuba, the first case of COVID-19 was …

CD6 is associated with T-cell modulation and is implicated in several autoimmune diseases.
We previously demonstrated that Itolizumab, a CD6 domain 1 (CD6D1) specific humanized …

Itolizumab is a first-in-class anti-CD6 monoclonal antibody that was initially developed for
various cancers and was later developed and approved in India for treatment of moderate to …

Introduction Defective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-
draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid …

Cancer management still requires more potent and safer treatments, of which
immunomodulatory receptors on the lymphocyte surface have started to show promise in …

The CD6 molecule is a pan T cell marker involved in T cell regulation. Although CD6
expression has been correlated with human autoimmune diseases, only a few therapeutic …