Despite nearly two decades passing since the discovery of gene fusions involving TFE3 or
TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the …

Monocyte lineage cells play important roles in health and disease. Their differentiation into
macrophages is crucial for a broad array of immunologic processes that regulate …

Selenoproteins containing selenium in the form of selenocysteine are critical for bone
remodeling. However, their underlying mechanism of action is not fully understood. Herein …

Introduction Rheumatoid arthritis (RA), which affects nearly 1% of the world's population, is a
debilitating autoimmune disease. Bone erosion caused by periarticular osteopenia and …

Abstract Purpose of Review The purpose of this review is to summarize the different roles of
the transcription factor SP7 in regulating bone formation and remodeling, discuss current …

Abnormal osteoclast formation and resorption play a fundamental role in osteoporosis
pathogenesis. Over the past two decades, much progress has been made to target …

Osteoclasts are the specialised cells that resorb bone matrix and are important both for the
growth and sha** of bones throughout development as well as during the process of bone …

Skeletal health is maintained by bone remodeling, a process in which microscopic sites of
effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently …

Mechanical loading of mammalian tissues is a potent promoter of tissue growth and
regeneration, whilst unloading in microgravity can cause reduced tissue regeneration …

Bone is a dynamic tissue constantly renewed through a regulated balance between bone
formation and resorption. Excessive bone degradation by osteoclasts leads to pathological …