Calcium ions are highly versatile intracellular signals that regulate many cellular processes.
The key to achieving this pleiotropic role is the spatiotemporal control of calcium …

Human malignant hyperthermia is a life‐threatening genetic sensitivity of skeletal muscles to
volatile anaesthetics and depolarizing neuromuscular blocking drugs occurring during or …

Dantrolene is a drug that suppresses intracellular Ca 2+ release from sarcoplasmic
reticulum (SR) in skeletal muscle and is used as a therapeutic agent in individuals …

Interdomain interactions between N-terminal and central domains serving as a" domain
switch" are believed to be essential to the functional regulation of the skeletal muscle …

It has long been known that skeletal muscle contraction persists in the absence of
extracellular Ca2+. Nevertheless, recent evidence indicates that multiple distinct Ca2+ entry …

Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that
dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca …

Mechanochemistry, as an enabling technology, harnesses mechanical force to drive
chemical reactions, presenting compelling advantages in organic synthesis within the …

The term excitation-coupled Ca2+ entry (ECCE) designates the entry of extracellular Ca2+
into skeletal muscle cells, which occurs in response to prolonged depolarization or pulse …

For more than 25 years, Dr. Charles Ciccone has been the forerunner in hel** physical
therapists explore how medications affect patient rehabilitation. And he's been updating his …

The two major calcium (Ca 2+) release channels on the sarco/endoplasmic reticulum
(SR/ER) are inositol 1, 4, 5-trisphosphate and ryanodine receptors (IP 3 Rs and RyRs). They …