T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …

Extracellular adenosine is elevated in cancer tissue, and it negatively regulates local
immune responses. Adenosine production from extracellular ATP has attracted attention as …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Tumors use several strategies to evade immunosurveillance. One such mechanism is the
generation of adenosine within the tumor microenvironment, which potently suppresses …

Extracellular adenosine is a potent immunosuppressor that accumulates during tumor
growth. We performed proof-of-concept studies investigating the therapeutic potential and …

Over recent years, significant advances in cancer immunotherapy have been made due to a
better understanding of the principles underlying tumor biology and immunology. In this …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Introduction: Cancer cells apply various mechanisms to induce and enhance immune
escape. The complex network of immune-response modulating factors in the tumor …