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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
[HTML][HTML] Biological functions and analytical strategies of sialic acids in tumor
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …
[HTML][HTML] The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
M Wenes, A Jaccard, T Wyss, N Maldonado-Pérez… - Cell metabolism, 2022 - cell.com
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
Targeting the siglec–sialic acid immune axis in cancer: current and future approaches
The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an
evolutionarily conserved immunoregulatory pathway that provides a mechanism for …
evolutionarily conserved immunoregulatory pathway that provides a mechanism for …
Metabolic signaling in cancer metastasis
S Krieg, SI Fernandes, C Kolliopoulos, M Liu… - Cancer …, 2024 - aacrjournals.org
Metastases, which are the leading cause of death in patients with cancer, have metabolic
vulnerabilities. Alterations in metabolism fuel the energy and biosynthetic needs of …
vulnerabilities. Alterations in metabolism fuel the energy and biosynthetic needs of …
[HTML][HTML] Understanding glycosylation: Regulation through the metabolic flux of precursor pathways
Glycosylation is how proteins and lipids are modified with complex carbohydrates known as
glycans. The post-translational modification of proteins with glycans is not a template-driven …
glycans. The post-translational modification of proteins with glycans is not a template-driven …
Recent advances in glycoproteomic analysis by mass spectrometry
Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …
modification is exceptionally complex because glycans are highly diverse and can be …
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis
Cancer metastasis requires the transient activation of cellular programs enabling
dissemination and seeding in distant organs. Genetic, transcriptional and translational …
dissemination and seeding in distant organs. Genetic, transcriptional and translational …
Siglec and anti-Siglec therapies
Siglecs (sialic acid–binding immunoglobulin-like lectins) are a family of receptors that bind
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …
Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells
Upregulation of surface expressed sialoglycans on tumor cells is one of the mechanisms
which promote tumor growth and progression. Specifically, the interactions of sialic acids …
which promote tumor growth and progression. Specifically, the interactions of sialic acids …